Structural biology has evolved considerably after the first breakthrough in understanding the molecular structure of DNA in 1950's. Nobel prize was awarded to them (Physiology/Medicine, 1962) for such an incredible discovery. This year's (2009) Nobel prize for chemistry goes to for their work on structural understanding of ribosomal machinery using X-ray crystallography. Nobel committee believe that this discovery is significant for the structure-based drug design of new antibiotics, especially since the emergence of bacterial resistance.
My thought here is "Will structure-based computational drug design methods bring some breakthrough discoveries in the next 20 years?"