Influence of protein shape and conformation on Drug Binding; Lock and key, Induced fit and beyond?

Intrinsic Changes In Protein Shape Influence Drug Binding

"According to the classical view, known as "induced fit," drug binding causes a change in the target protein structure......But it now appears that a protein has many different conformations that are already available even without the presence of a binding molecule, which is called the ligand. The ligand attaches to the protein shape that allows it to fit well, and that close interaction can lead to effective inhibition of protein function...."

Well, the thought process was on the horizon for sometime...

PNAS Article

Why the Pfizer layoff? narrowing its research focus? Cardiovascular research abandoned.

"The move comes after the company announced in September it was narrowing its research focus to six disease areas  Alzheimer's, cancer, schizophrenia, pain, inflammation and diabetes"...


"Surprisingly, one of the areas abandoned was cardiovascular disease, where Pfizer had been a dominant player with its $13 billion-a-year cholesterol fighter Lipitor, the world's top-selling drug..."

Drugmaker Pfizer cutting up to 800 scientist jobs - washingtonpost.com

More drug approvals from FDA is a welcome sign

More approvals are welcome. Industry accuses FDA for not being efficient. At the same time, one should not forget about incidents like Vioxx tragedy

FDA Approves More Drugs, Still Misses Deadlines

FDA Warns Consumers About Tainted Weight Loss Pills

Health hazard from online pharmacies? See the FDA report published yesterday.

FDA Warns Consumers About Tainted Weight Loss Pills

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